Progenesis SameSpots V2.0

Nonlinear Dynamics Ltd is a UK company based in Newcastle upon Tyne. The company develops innovative products for solving problems in proteomics, genomics, biomarker discovery and clinical diagnostics. The Company's product portfolio comprises high-quality analysis and data mining tools for 1D and 2D electrophoresis gels and microarrays, the core technologies of genomics and proteomics.

The company's product 'Progenesis' is the 2D image analysis solutions for the scientist who requires an in-depth view of their proteomics experiments to drive their research. 'Progenesis SameSpots' enhances the analysis workflow with significant improvements in speed, objectivity and statistical power.

The software helps the analysis of 2D single stain and DIGE images for proteomics research. The unique image alignment of SameSpots offers users a streamlined, faster 2D workflow, largely through the elimination post analysis editing. This significantly speeds up the 2D analysis process and reduces the subjectivity of user-operated editing. The SameSpots approach also provides increased statistical power, which generates reliable results that can be used with confidence.

The company announced yesterday that the Japanese National Cancer Research Institute is using 'Progenesis SameSpots' to identify biomarker candidates that could predict the efficacy of chemotherapy for patients of lung cancer. The new technology has quickly shown its value. Dr. Kondo and his group are identifying biomarker candidates for prediction of response to the chemotherapy (gefitinib, Iressa) in lung adenocarcinoma using Progenesis SameSpots. This is important research because in Japan, while the incidence of stomach cancer is decreasing those of lung, colorectal and breast cancers are increasing.

Dr Kondo, who is leading the group, said: "In clinical proteome research, many samples must be analyzed because of individual differences. We are currently running more than 1500 2D-DIGE gels per year. Progenesis SameSpots accurately analyzes such large gel numbers in a very short period. We also need to use data-mining tools effectively, which makes matching very important. Progenesis SameSpots generates good data for data-mining study."

A trial version of Progenesis SameSpot can be downloaded from: http://www.samespots.com/try_it.asp.

Other Links: Nonlinear Dynamics, National Cancer Research Institute,